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METTLER TOLEDO Introduces an Affordable Reaction Block for SolidPhase...

Peptide libraries are widely investigated and routinely screened for their drug-like properties. Synthesis using resins or solid supports is a favorite route for researchers performing peptide synthesis. However, synthesis and subsequent purification are major bottlenecks encountered during synthesis of peptide libraries.

Applications using novel solid supported reagents in combination with solid phase synthesis and parallel purification are reported to produce diverse, drug like library of hindered amides, dipeptides, and tripeptides with minimal purification in parallel arrays. These reactions are effectively performed in the METTLER TOLEDO MiniBlock's174; with the peptide coupling steps (http://www.mt.com/global/en/home/supportive_content/promotions.Peptide-SPPS.twoColEd.htmlcrel=US_AC_eAdv_Peptide20090621)performed in one block followed by transfer of the reaction components in parallel to a second MiniBlock's174; containing ion exchange resin. After agitation, the reaction mixtures were free of salt by-products and pure dipeptides were released into a deep well plate and evaporated.

Eliminate bottlenecks and improve peptide synthesis and purification with METTLER TOLEDO MiniBlock's174; peptide synthesis sets and packages. MiniBlock's174; is a cost effective and scalable platform for solid phase peptide synthesis enabling the synthesis of arrays and libraries from 6 to 96 peptides and is a viable alternative to traditional techniques like SPOT synthesis.

For a limited time*, you can register to win a MiniBlock's174; to improve Solid Phase Peptide Synthesis (SPPS) (http://www.mt.com/global/en/home/supportive_content/promotions.Peptide-SPPS.twoColEd.htmlcrel=US_AC_eAdv_Peptide20090621).

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